What question did this study set out to answer?

To evaluate whether adjunctive immune-stimulatory therapy with recombinant interferon-gamma improves host immune function in patients with severe invasive fungal infections.

March 26, 2014BMC Infectious DiseasesOpen Access

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

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To evaluate whether adjunctive immune-stimulatory therapy with recombinant interferon-gamma improves host immune function in patients with severe invasive fungal infections.
Interventional prospective study (NCT01270490) evaluating eight patients with invasive Candida and/or Aspergillus infections.
Patients received recombinant interferon-gamma (100 μg subcutaneously, three times weekly) for two weeks in combination with standard antifungal therapy.
Recombinant interferon-gamma treatment partially restored immune function across treated fungal infection patients.
Therapy increased HLA-DR expression in individuals with baseline levels below 50% and enhanced leukocyte production of antifungal proinflammatory cytokines.

Authors

CDCorine DelsingMedisch Spectrum Twente MGMark S. GresnigtLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)JLJenneke LeentjensRadboud University Nijmegen

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Implication

Randomized trial demonstrates partially restored immune function in invasive fungal infection patients, suggesting adjunctive immunotherapy may bolster host defense.

Cite This Study

Delsing et al. (2014) studied this question.

synapsesocial.com/papers/6a8824c9a95381ace1bbfe58 https://doi.org/10.1186/1471-2334-14-166

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Implication

Randomized trial demonstrates partially restored immune function in invasive fungal infection patients, suggesting adjunctive immunotherapy may bolster host defense.

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

Key Points

Discussion

Implication

Cite This Study

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

Key Points

Discussion

Implication

Cite This Study

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