Key result
Depression affects 20% to 25% of patients with predialysis chronic kidney disease and is associated with poor medical outcomes, though its link to mortality remains unclear.
Why the study?
Although depression is clearly associated with increased mortality in ESRD, its association with mortality in patients with CKD remains less clear.
Depression is highly prevalent in CKD and is linked to adverse renal and cardiovascular outcomes, though its impact on mortality remains unclear.
Depression warrants clinical attention in predialysis CKD; leaves open mortality impact and need for prospective intervention trials.
Depression is common in patients with predialysis chronic kidney disease (CKD), with prevalence rates of approximately 20% to 25%.1 In patients with CKD, depression is associated with poor medical outcomes, including a higher risk of acute kidney injury, CKD progression, and cardiovascular events.2 Although depression has been clearly associated with increased mortality in patients with end-stage renal disease (ESRD),2 the association between depression and mortality in patients with CKD is less clear.
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Shayan Shirazian (2018) conducted a review in Chronic kidney disease and depression. Depression was evaluated. Depression affects 20% to 25% of patients with predialysis chronic kidney disease and is associated with poor medical outcomes, though its link to mortality remains unclear.
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