What question did this study set out to answer?

To report atypical clinical manifestations in pathologically confirmed cases of progressive supranuclear palsy that deviate from classic diagnostic criteria.

April 1, 1985Annals of Neurology

Atypical presentation of progressive supranuclear palsy

View Full Paper

Ask AI

Bookmark

Authors

PDPatricia H. DavisNorthwestern University CBC. BergeronFlorida State University DMD. R. Crapper McLachlanUniversity of Pisa

Discussion

Member takes

Implication

Case series reveals atypical presentations lacking classic ophthalmoplegia in progressive supranuclear palsy, highlighting risks of underdiagnosis when applying rigid criteria.

Key Points

To report atypical clinical manifestations in pathologically confirmed cases of progressive supranuclear palsy that deviate from classic diagnostic criteria.
Retrospective clinical analysis of four pathologically confirmed cases (N=4) of progressive supranuclear palsy.
Evaluation of patient presentation, neurological symptoms, and response to levodopa-carbidopa therapy.
Two patients presented predominantly with severe dementia and two with parkinsonism; none manifested classic ophthalmoplegia.
Retrospective clues indicating the disease included early prominent gait disturbance, poor response to levodopa-carbidopa, absent tremor, apraxia of eyelid opening (n=1), and terminal neck extension rigidity (n=1).

Cite This Study

Davis et al. (1985) studied this question.

synapsesocial.com/papers/6a882699729e8aa7bb583a33 https://doi.org/10.1002/ana.410170406

View Full Paper

Ask AI

Bookmark

Implication

Case series reveals atypical presentations lacking classic ophthalmoplegia in progressive supranuclear palsy, highlighting risks of underdiagnosis when applying rigid criteria.

Atypical presentation of progressive supranuclear palsy

Discussion

Member takes

Implication

Key Points

Cite This Study

Atypical presentation of progressive supranuclear palsy

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider