Why the study?
Does myocardial ischaemia attenuate the response to inotropic interventions (heart rate and paired ventricular pacing) in isolated canine hearts?
Population
15 isolated perfused isovolumic canine hearts
Comparison
Inotropic interventions during ischaemic perfusion vs Inotropic interventions with normal perfusion…
Design
Preclinical
Authors
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Ischaemia may blunt inotropic responses to rate and pacing; extends animal observations but leaves open human translation.
Does myocardial ischaemia attenuate the response to inotropic interventions (heart rate and paired ventricular pacing) in isolated canine hearts?
Myocardial ischaemia severely limits the effectiveness of inotropic interventions such as increased heart rate and paired ventricular pacing in augmenting cardiac performance.
Serur et al. (1973) studied this question.
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