What question did this study set out to answer?

To review the pathogenesis, clinical diagnostic modalities, therapeutic strategies, and artificial intelligence applications in the management of prion diseases.

July 10, 2025CNS & Neurological Disorders - Drug Targets

Insights into the Diagnosis, Treatment, and Management of Prion Diseases

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Authors

VCVania Austine CallistaInternational Medical University KHKetan HatwareNarsee Monjee Institute of Management Studies PIPravinkumar Vishwanath IngleInternational Medical University

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Implication

Review demonstrates evolving diagnostic and therapeutic strategies for prion diseases, highlighting artificial intelligence and targeted gene therapies as critical frontiers.

Key Points

To review the pathogenesis, clinical diagnostic modalities, therapeutic strategies, and artificial intelligence applications in the management of prion diseases.
Synthesized evidence on molecular mechanisms underlying the conversion of cellular prion protein (PrPC) to pathogenic aggregates (PrPSc).
Evaluated diagnostic utility across real-time quaking-induced conversion (RT-QuIC), neuroimaging, electroencephalography, and cerebrospinal fluid biomarkers.
Assessed experimental therapeutics including antisense oligonucleotides, monoclonal antibodies, autophagy enhancers, and artificial intelligence-assisted discovery platforms.
Real-time quaking-induced conversion (RT-QuIC) assays demonstrate high diagnostic sensitivity and specificity for detecting pathological prion aggregates.
Experimental therapeutic modalities targeting PrP misfolding, including gene-silencing therapies and monoclonal antibodies, show potential to slow progression beyond palliative care.
Artificial intelligence models improve diagnostic accuracy by decoding neuroimaging patterns and accelerate drug repurposing and candidate screening.

Cite This Study

Callista et al. (2025) studied this question.

synapsesocial.com/papers/6a882809054eefc4d776f769 https://doi.org/10.2174/0118715273381241250620114740

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Implication

Review demonstrates evolving diagnostic and therapeutic strategies for prion diseases, highlighting artificial intelligence and targeted gene therapies as critical frontiers.

Insights into the Diagnosis, Treatment, and Management of Prion Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Insights into the Diagnosis, Treatment, and Management of Prion Diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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