What question did this study set out to answer?

To evaluate the clinical utility and technical feasibility of detecting circulating cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis.

October 22, 2008Human Reproduction Update

The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis

View Full Paper

Ask AI

Bookmark

Authors

CWCaroline F. WrightUniversity of Exeter HBH. BurtonWashington University in St. Louis

Discussion

Member takes

Implication

Systematic review demonstrates the utility of maternal cell-free fetal nucleic acids for prenatal genetic testing, indicating substantial potential for routine non-invasive screening.

Key Points

To evaluate the clinical utility and technical feasibility of detecting circulating cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis.
Systematically searched PubMed using the terms 'free fetal DNA' and 'NIPD'.
Screened reference lists of relevant publications to ensure comprehensive coverage of molecular detection and clinical applications.
Cell-free fetal DNA accounts for 3% to 6% of total circulating cell-free DNA from 5 weeks of gestation and clears rapidly postpartum, primarily permitting detection of paternally inherited sequences and fetal-placental gene expression patterns.
Key clinical applications encompass identifying paternally inherited monogenic disorders, sex determination for X-linked conditions, fetal RhD genotyping, and aneuploidy detection including Down syndrome.
Fetal sex determination and RhD genotyping are actively translating into clinical practice for high-risk pregnancies, with broader potential for incorporation into national antenatal screening programmes.

Cite This Study

Wright et al. (2008) studied this question.

synapsesocial.com/papers/6a88281ba082a64c2914bf80 https://doi.org/10.1093/humupd/dmn047

View Full Paper

Ask AI

Bookmark

Implication

Systematic review demonstrates the utility of maternal cell-free fetal nucleic acids for prenatal genetic testing, indicating substantial potential for routine non-invasive screening.

The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis

Discussion

Member takes

Implication

Key Points

Cite This Study

The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider