Key result
RNA helicase DDX1 binds to G-quadruplex structures in intronic switch transcripts and converts them into R-loops, targeting AID to S-regions and promoting IgH class switch recombination.
Population
In vivo and in vitro models of IgH class switch recombination
Comparison
DDX1 ATPase-deficient mutant expression or… vs Wild-type or untreated controls
Design
Preclinical
Authors
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Advances molecular view of class switching; hypothesis-generating with no immediate clinical implications.
The RNA helicase DDX1 is essential for converting RNA G-quadruplex structures into R-loops to promote IgH class switch recombination.
Almeida et al. (2018) studied this question. RNA Helicase DDX1 was evaluated on Class switch recombination (CSR) efficiency. RNA helicase DDX1 binds to G-quadruplex structures in intronic switch transcripts and converts them into R-loops, targeting AID to S-regions and promoting IgH class switch recombination.
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