Population
In vitro biochemical models (MYPT1)
Design
Preclinical
Authors
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May identify DMPK as Rho-kinase-independent regulator of contractility; hypothesis-generating for new targets in smooth muscle disorders.
DMPK, like Rho-kinase, can regulate myosin II phosphorylation by phosphorylating MYPT1 at T654 and inhibiting myosin phosphatase activity.
Murányi et al. (2001) studied this question.
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