Carcinomatous Neuropathy

Case Reports1 June 1961CARCINOMATOUS NEUROPATHYMONROE THOMAS DIAMOND, M.D., F.A.C.P.MONROE THOMAS DIAMOND, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1259 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONIt has long been noted that disorders of the nervous system can occur in association with malignancy and yet be unrelated to the presence of metastases. As far back as 1888 Oppenheim1reported the occurrence of peripheral neuritis in malignant disease, and suggested that this was the result of a toxic process. Nonne2in 1900 and Siefert3in 1902 supported this view. In 1908 Williamson4stated that posterior column degeneration had been seen in cases of cachexia associated with cancer of various organs, and in 1919 subacute cortical cerebellar degeneration was described in association with neoplasms by Brouwer5and Jelgersma.6...Bibliography1. Oppenheim H: Ueber hirnsymptome bei carcinomatose ohne nachweisbare veränderungenim gehirn. Charité-Ann. 13: 335, 1888. Google Scholar2. Nonne M: Discussion of Saenger's cases. Neurol. Centralbl. 19: 187, 1900. Google Scholar3. Siefert E: Ueber die multiple carcinomatose des central nervensystems. Müenchen. Med. Wschr. 49: 826, 1902. Google Scholar4. Williamson RT: Diseases of spinal cord. Oxford University Press, London, 1908, p. 377. Google Scholar5. Brouwer B: Beitrag zur kenntnis der chronisohen diffusen kleinhirnerkrankungen. Neurol. Centralbl. 38: 674, 1919. Google Scholar6. Jelgersma G: Eine systemerkrankung in kleinhirn. J. Psychol. Neurol. 25: 42, 1919. Google Scholar7. Hassin GB: Histopathology of carcinoma of the cerebral meninges. Arch. Neurol. Psychiat. 1: 705, 1919. CrossrefGoogle Scholar8. HassinSinger GBHD: Histology of cerebral carcinoma. Arch. Neurol. Psychiat. 8: 155, 1922. CrossrefGoogle Scholar9. Lhermitte J: L'astasie—abasie cérébelleuse par atrophie vermenner chez le vieillard. Rev. Neurol. 29: 3113, 1922. Google Scholar10. Harris W: Neuritis and neuralgia. H. Milford, London, 1926, p. 38. Google Scholar11. Casper J: Toxische kleinhirnatrophie bei brustkrebs. Zbl. Ges. Neurol. Psychiat. 53: 854, 1929. Google Scholar12. WeberHill FPTL: Complete degeneration of the posterior columns of the spinal cord with chronic polyneuritis in a case of widespread carcinomatous disease elsewhere. J. Neurol. Psychopath. 14: 57, 1933. CrossrefMedlineGoogle Scholar13. ParkerKernohan HLJW: Parenchymatous cortical cerebellar atrophy (chronic atrophy of Perkinje's cells). Brain 56: 191, 1933. CrossrefGoogle Scholar14. Greenfield JG: Subacute spino-cerebellar degeneration occurring in elderly patients. Brain 57: 161, 1934. CrossrefGoogle Scholar15. Wexburgia E: Handbuch der neurologie, edited by Bumke, O., and Foerster, O., Vol. IX, Springer, Berlin, 1935-37, p. 113. Google Scholar16. Kennard MA: Clinical and histological observations on a case of primary cortical degeneration of the cerebellum. Akad. Wet., Amsterdam, Proc. 38: 544, 1935. Google Scholar17. Zülch KJ: Uber die primare kleinhirneindenatrophie. Z. Neurol. Psychiat. 156: 493, 1936. CrossrefGoogle Scholar18. MerrittFremont-Smith MHF: The cerebrospinal fluid, W. B. Saunders Co., Philadelphia, 1937, p. 183. Google Scholar19. Kendall D: An unusual case of sensory polyneuritis. Proc. Roy. Soc. Med. 32: 874, 1939. CrossrefMedlineGoogle Scholar20. Alessi D: Lesioni parenchimatose del cervelletto da carcinoma uterino (gliosi carcinotossica?). Sintomatologio dissivergico—mioclonica. Riv. di Pat. Nerv. Ment. 55: 148, 1940. Google Scholar21. GareinBertrandGodet-Guillain RIJ: Étude d' anatomo—chronique d'un cas d'atrophie cérébelleuse tardive à predominance corticate avec lésions neuroganglionnoyes des noyous dentetes. Rev. Neurol. 72: 724, 1940. Google Scholar22. Wilson SA: Neurology, Vol. 1. The Williams & Wilkins Company, Baltimore, 1940, p. 185. Google Scholar23. BertrandGodet-Guillain IJ: Etude anatomo-clinique d'un cas d'atrophie la mellaire cerebelleuse. Rev. Neurol. 74: 287, 1943. Google Scholar24. Meerloo AM: The initial neurological and psychiatric syndrome of pulmonary growth. J. A. M. A. 126: 558, 1944. CrossrefGoogle Scholar25. BrouwerSchlesinger BFG: Carcinoma ovarii and cerebellar degeneration. K. Akad. Wet. Amsterdam Proc. 50: 1329, 1947. Google Scholar26. Wyburn-Mason R: Bronchial carcinoma presenting as polyneuritis. Lancet 1: 203, 1948. CrossrefMedlineGoogle Scholar27. Denny-Brown D: Primary sensory neuropathy with muscular changes associated with carcinoma. J. Neurol., Neurosurg., Psychiat. 11: 73, 1948. CrossrefMedlineGoogle Scholar28. Zülch KP: Uber die anatomische stellung der kleinhirnrindenatrophie und ihre beziehung zur nonne-marieschen krankheit. Deutsch. Z. Nervenheilk 159: 501, 1948. CrossrefGoogle Scholar29. LeighMeyer ADA: Degeneration of the granular layer of the cerebellum. J. Neurol., Neurosurg., Psychiat. 12: 287, 1949. CrossrefMedlineGoogle Scholar30. LennoxPrichard BS: The association of bronchial carcinoma and peripheral neuritis. Quart. J. Med. 19: 97, 1950. MedlineGoogle Scholar31. BrainDanielGreenfield WRPMJG: Subacute cortical cerebellar denegeration and its relation to carcinoma. J. Neurol. Neurosurg., Psychiat. 14: 59, 1951. CrossrefMedlineGoogle Scholar32. ElkingtonThompsonMatthews JSRHWB: Discussion: recent work on the peripheral neuropathies. Proc. Roy. Soc. Med. 45: 661, 1952. CrossrefMedlineGoogle Scholar33. Heathfield RW: Peripheral neuritis and carcinoma of bronchus. Proc. Roy. Soc. Med. 45: 229, 1952. Google Scholar34. KremerPratt MR: Sensory neuropathy. Proc. Roy. Soc. Med. 45: 230, 1952. Google Scholar35. DodgsonHoffman MCHL: Sensory neuropathy associated with carcinoma of the esophagus. Report of a case. Ann. Intern. Med. 38: 130, 1953. LinkGoogle Scholar36. Barroquer-BordasLowenthal LA: Le syndrome cérébelleux preterminal des carcinoses. Mschr. Psychiat. Neurol. 125: 239, 1953. CrossrefMedlineGoogle Scholar37. Henson RA: Discussion on unusual manifestations on bronchial carcinoma. Section of medicine, Proc. Roy. Soc. Med. 46: 859, 1953. MedlineGoogle Scholar38. Ironside R, from Henson, R., Russell, D., and Wilkinson, M.: Carcinomatous neuropathy and myopathy. A clinical and pathological study. Brain 77: 82, 1954 (personal communication to authors, p. 116). CrossrefMedlineGoogle Scholar39. HensonRussellWilkinson RDM: Carcinomatous neuropathy and myopathy. A clinical and pathological study. Brain 77: 82, 1954. CrossrefMedlineGoogle Scholar40. HeathfieldWilliams KWJR: Peripheral neuropathy and myopathy associated with bronchogenic carcinoma. Brain 77: 122, 1954. CrossrefMedlineGoogle Scholar41. Greenfield JG: The spinocerebellar degenerations. Charles C Thomas, Springfield, Ill., 1954. Google Scholar42. BrainStrauss REB: Recent advances in neurology and neuropsychiatry, 6th Ed. Little, Brown and Co., Boston, 1955, pp. 155-158. Google Scholar43. CharatanBrierly FBJB: Mental disorder associated with primary lung carcinoma. Brit. Med. J. 1: 765, 1956. CrossrefMedlineGoogle Scholar44. BrainHenson RRA: Neurological syndromes associated with carcinoma. The carcinomatous neuromyopathies. Lancet 2: 971, 1958. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chappaqua, N. Y.*Received for publication December 28, 1959.Requests for reprints should be addressed to Monroe Thomas Diamond, M.D., 175 King Street, Chappaqua, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPRETREATMENT URINARY HORMONE PATTERNS AND SURVIVAL IN PATIENTS WITH BREAST CANCER, PROSTATE CANCER, OR LUNG CANCERPARANEOPLASTIC DISORDERSAbnormalities in urinary hormone patterns in lung cancer and emphysemaPure motor neuropathy complicating carcinoma of bronchus recovered after surgeryNonmetastatic neurological complications of bronchogenic carcinoma: The carcinomatous neuromyopathiesEndocrine Dysfunction in Malignant DiseaseA review of unusual systemic manifestations associated with carcinomaNeuromuscular disorders associated with malignant neoplastic diseaseBronchogenic Carcinoma Associated with Severe Orthostatic HypotensionJAN K. SIEMSEN, M.D., LESTER MEISTER, M.D. 1 June 1961Volume 54, Issue 6Page: 1259-1266KeywordsBrainNervous systemNeuromuscular diseasesNeuropathy ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...