Studies were conducted to determine whether the gastric mucosal circulation responds more to histamine than to extracted porcine gastrin or to a synthetic gastrin-like peptide. In conscious dogs provided with a gastric fistula, the stomach was stimulated to secrete at submaximal rates with each agent. At comparable secretory rates gastric mucosal blood flow was greater with histamine than with either form of gastrin.
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Jacobson et al. (1969) studied this question.