Key result
Shear wave velocity measured by combinational elastography was significantly higher in patients with heart failure compared to healthy controls (1.68 vs 1.21 m/s) and decreased significantly after treatment.
Why the study?
Shear wave velocity varies with both fibrosis and congestion, while the LF index reflects only fibrosis progression, leaving the utility of these elastography methods in heart failure patients unclear.
Does combinational elastography accurately assess liver congestion and differentiate it from liver fibrosis in patients with heart failure?
Population
51 patients with HF (33 outpatients and 18 inpatients) and 10 healthy participants
Comparison
HF patients vs healthy participants, and pre- vs post-treatment in 18 inpatients
Design
Prospective study
Authors
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May support monitoring liver congestion in heart failure; leaves open reliable differentiation from fibrosis pending prospective validation.
Observational (n=61)
Single-blind
No
Does combinational elastography accurately assess liver congestion and differentiate it from liver fibrosis in patients with heart failure?
Absolute Event Rate: 1.68% vs 1.21%
p-value: p=0.002
Combinational elastography is a useful noninvasive tool to assess liver congestion and monitor therapeutic response in heart failure patients, effectively distinguishing congestion from true liver fibrosis.
Sakamoto et al. (2022) conducted an observational in Heart Failure (n=61). Heart failure vs. Healthy controls was evaluated on Shear wave velocity (Vs) (p=0.002). Shear wave velocity measured by combinational elastography was significantly higher in patients with heart failure compared to healthy controls (1.68 vs 1.21 m/s) and decreased significantly after treatment.
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