Key result
The fibrosis-4 index is a significant predictor of all-cause mortality in patients with pulmonary hypertension due to left heart disease (HR 1.212).
Why the study?
Does the Fibrosis-4 index predict mortality in patients with pulmonary hypertension due to left heart disease?
Cohort (n=230)
No
Does the Fibrosis-4 index predict mortality in patients with pulmonary hypertension due to left heart disease?
Hazard Ratio: 1.212 (95% CI 1.099–1.337)
p-value: p=< 0.001
The Fibrosis-4 index is a useful, non-invasive predictor of all-cause mortality in patients with pulmonary hypertension due to left heart disease.
FIB-4 may aid mortality risk stratification in PH-LHD; hypothesis-generating and requires prospective validation.
/L) ]. We followed patients for all-cause mortality during the follow-up period (mean 1112 ± 822 days).The patients were divided into tertiles based on their fibrosis-4 index: the first tertile 0.335 to 1.381; the second tertile 1.391 to 2.311; and the third tertile 2.323 to 14.339. Compared with the first tertile, the third tertile had lower estimated glomerular filtration rates and hemoglobin levels. All-cause mortality was significantly higher in the third than in the first tertile. In a Cox proportional hazard model, the fibrosis-4 index was a predictor of all-cause mortality in PH-LHD patients (HR 1.212, 95% CI 1.099-1.337, P < 0.001).The fibrosis-4 index is associated with kidney function, anemia, and high mortality in PH-LHD patients.
No takes yet. Share an insight, caveat, or question.
Yokokawa et al. (2019) conducted a cohort in Pulmonary hypertension due to left heart disease (PH-LHD) (n=230). Fibrosis-4 index vs. Lower Fibrosis-4 index was evaluated on All-cause mortality (HR 1.212, 95% CI 1.099-1.337, p=< 0.001). The fibrosis-4 index is a significant predictor of all-cause mortality in patients with pulmonary hypertension due to left heart disease (HR 1.212).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: