Key result
Ascending aortic aneurysm was associated with significantly lower carotid intima-media thickness compared to controls (0.50 vs 0.60 mm; adjusted difference -0.131 mm, p=0.0002).
Why the study?
Does the presence of ascending aortic aneurysm associate with reduced carotid intima-media thickness compared to controls?
Population
81 individuals (52 patients with ascending aortic aneurysms and 29 controls)
Comparison
Presence of ascending aortic aneurysm vs Controls without ascending aortic aneurysm
Design
Case-control
Authors
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No immediate clinical implications; hypothesis-generating for proaneurysmal mutations protecting against atherosclerosis.
Case-Control (n=81)
Does the presence of ascending aortic aneurysm associate with reduced carotid intima-media thickness compared to controls?
Mean Difference: -0.131
Absolute Event Rate: 0.5% vs 0.6%
p-value: p=0.0002
Ascending aortic aneurysm is associated with lower carotid intima-media thickness, providing evidence that proaneurysmal genetic mutations may protect against systemic atherosclerosis.
Hung et al. (2012) conducted a case-control in Ascending aortic aneurysm (n=81). Ascending aortic aneurysm vs. Controls was evaluated on Carotid intima-media thickness (IMT) (MD -0.131, p=0.0002). Ascending aortic aneurysm was associated with significantly lower carotid intima-media thickness compared to controls (0.50 vs 0.60 mm; adjusted difference -0.131 mm, p=0.0002).
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