Key result
Perivascular leptin overexpression and visceral adipose tissue transplantation promoted neointima formation in mice, independent of systemic hyperleptinemia.
Why the study?
Does perivascular leptin overexpression or visceral adipose tissue transplantation promote neointima formation after carotid artery injury in mice?
Population
Mice models undergoing carotid artery injury, and human arterial smooth muscle cells in vitro
Comparison
Perivascular leptin overexpression via… vs Leptin receptor-deficient mice, or perivascular…
Design
Preclinical
Authors
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Local leptin and perivascular fat may promote restenosis; leaves open translation to human vascular injury.
Does perivascular leptin overexpression or visceral adipose tissue transplantation promote neointima formation after carotid artery injury in mice?
Locally elevated leptin levels and perivascular inflammation from adipose tissue promote neointima formation independent of systemic obesity and hyperleptinemia.
Schroeter et al. (2013) studied Neointima formation. Perivascular leptin overexpression and VAT transplantation vs. Leptin-deficient mice or wild-type controls was evaluated on Neointima formation. Perivascular leptin overexpression and visceral adipose tissue transplantation promoted neointima formation in mice, independent of systemic hyperleptinemia.
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