Key result
Lysophosphatidic acid/PKD-1 signaling suppresses endothelial CD36 transcription via FoxO1-HDAC7 complex formation, resulting in proangiogenic and proarteriogenic reprogramming.
The LPA/PKD-1 signaling cascade suppresses endothelial CD36 transcription via the FoxO1-HDAC7 complex, promoting proangiogenic and proarteriogenic reprogramming, which may serve as a novel therapeutic target for ischemic cardiovascular disease.
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Animal data link LPA/PKD-1 to proangiogenic reprogramming; leaves open whether CD36 targeting improves human ischemic outcomes.
Ren et al. (2016) studied Angiogenesis and arteriogenesis. Lysophosphatidic acid/PKD-1 signaling was evaluated on CD36 transcription and endothelial cell function. Lysophosphatidic acid/PKD-1 signaling suppresses endothelial CD36 transcription via FoxO1-HDAC7 complex formation, resulting in proangiogenic and proarteriogenic reprogramming.
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