Key result
A single immunization with spike-functionalized ferritin nanoparticles elicited significantly higher neutralizing antibody responses in mice compared to spike trimer or RBD alone, with titers at least 2-fold greater than convalescent human plasma.
Why the study?
Development of a safe and effective SARS-CoV-2 vaccine was an urgent public health priority.
Does immunization with spike-functionalized ferritin nanoparticles improve neutralizing antibody responses against SARS-CoV-2 in mice?
Does immunization with spike-functionalized ferritin nanoparticles improve neutralizing antibody responses against SARS-CoV-2 in mice?
Multivalent presentation of SARS-CoV-2 spike on ferritin nanoparticles enhances the elicitation of neutralizing antibodies in mice, suggesting a viable strategy for single-dose COVID-19 vaccination.
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May support single-dose vaccine strategies; hypothesis-generating in mice and leaves human translation open.
Powell et al. (2020) studied SARS-CoV-2 (n=50). Spike-functionalized ferritin nanoparticles (S-Fer and SΔC-Fer) vs. Spike trimer (S-GCN4, SΔC-GCN4) or RBD alone was evaluated on Neutralizing antibody titers. A single immunization with spike-functionalized ferritin nanoparticles elicited significantly higher neutralizing antibody responses in mice compared to spike trimer or RBD alone, with titers at least 2-fold greater than convalescent human plasma.
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