Metallo-Beta-Lactamase-Producing Multidrug-Resistant Acinetobacter Isolates in Patients with Ventilator-Associated Pneumonia

VirendraChandrashekhar Patil; HarshaVirendra Patil; ShivajiT Mohite

doi:10.4103/jnsbm.jnsbm_54_20

January 1, 2021Journal of Natural Science Biology and MedicineOpen Access

Metallo-Beta-Lactamase-Producing Multidrug-Resistant Acinetobacter Isolates in Patients with Ventilator-Associated Pneumonia

View Full Paper

Ask AI

Bookmark

Share

Key Points

To phenotypically detect metallo-beta-lactamase (MBL) production and assess antibiotic susceptibility patterns among multidrug-resistant (MDR) Acinetobacter isolates causing ventilator-associated pneumonia (VAP).
Prospective, observational, noninterventional study conducted over 2 years in an intensive care unit at a tertiary care teaching hospital.
Evaluated 188 clinical samples fulfilling the inclusion criteria for ventilator-associated pneumonia.
Screened MDR Acinetobacter isolates for MBL production using imipenem-EDTA double-disc synergy test (DDST), imipenem-EDTA combined disc synergy test (CDST-IPM), and MBL-E test.
Among 188 MDR Acinetobacter spp. isolates (76.42% of total isolates), 164 (87.23%) were identified as MBL producers and 24 (12.76%) were non-MBL producers.
MBL-producing strains demonstrated extensive antimicrobial resistance, substantially limiting available antibiotic treatment options.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Prospective observational study reveals high metallo-beta-lactamase rates among multidrug-resistant Acinetobacter in ventilator-associated pneumonia, highlighting severe therapeutic challenges.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Patil et al. (2021) studied this question.

synapsesocial.com/papers/6a8831d45ee6e03ae3cf15c8 https://doi.org/10.4103/jnsbm.jnsbm_54_20

View Full Paper

Ask AI

Bookmark

Share

Metallo-Beta-Lactamase-Producing Multidrug-Resistant Acinetobacter Isolates in Patients with Ventilator-Associated Pneumonia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Metallo-Beta-Lactamase-Producing Multidrug-Resistant Acinetobacter Isolates in Patients with Ventilator-Associated Pneumonia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading