Key result
Deletion of the cardiac Foxo1 gene largely prevented heart failure and decreased β-MHC expression in mouse models of insulin resistance and diabetes.
Why the study?
Does deletion of cardiac Foxo1 gene prevent cardiac dysfunction and alter β-MHC expression in mouse models of insulin resistance and diabetes?
Population
Mice lacking IRS1 and IRS2 in adult hearts, db/db mice, high-fat diet mice, and cultures of primary…
Comparison
Deletion of cardiac Foxo1 gene vs Mice with intact Foxo1 gene
Design
Preclinical
Authors
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Hypothesis-generating for Foxo1 targeting in diabetic cardiomyopathy; human studies needed before clinical consideration.
Does deletion of cardiac Foxo1 gene prevent cardiac dysfunction and alter β-MHC expression in mouse models of insulin resistance and diabetes?
Foxo1 promotes diabetic cardiomyopathy by controlling β-MHC expression, and its deletion prevents heart failure in insulin-resistant mouse models.
Qi et al. (2014) studied Heart failure and insulin resistance. Deletion of cardiac Foxo1 gene vs. Intact Foxo1 gene in disease models was evaluated on Heart failure and β-MHC gene expression. Deletion of the cardiac Foxo1 gene largely prevented heart failure and decreased β-MHC expression in mouse models of insulin resistance and diabetes.
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