Key result
Higher serum cardiac troponin I concentrations at admission in dogs with SIRS were significantly associated with 28-day mortality (median 0.63 ng/mL vs 0.09 ng/mL in survivors; P=0.004).
Why the study?
Does daily follow-up measurement of cTnI provide better prognostic information for 28-day mortality than a single measurement at admission in dogs with SIRS?
Population
60 dogs with systemic inflammatory response syndrome (SIRS)
Comparison
Daily follow-up measurement of cardiac troponin… vs Single cTnI measurement at admission
Design
Cohort
Follow-up
28 days
Authors
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Admission cTnI may aid short-term prognosis in canine SIRS; leaves open whether serial measurements add incremental value.
Observational (n=60)
Does daily follow-up measurement of cTnI provide better prognostic information for 28-day mortality than a single measurement at admission in dogs with SIRS?
Effect estimate: AUC 0.732
p-value: p=0.004
In dogs with SIRS, increased cTnI is associated with poor outcome, but daily follow-up measurements do not provide additional prognostic information over a single admission measurement.
Hamacher et al. (2015) conducted an observational in Systemic Inflammatory Response Syndrome (SIRS) (n=60). Serum cardiac troponin I (cTnI) concentration vs. Lower cTnI concentration was evaluated on 28-day mortality (AUC 0.732, p=0.004). Higher serum cardiac troponin I concentrations at admission in dogs with SIRS were significantly associated with 28-day mortality (median 0.63 ng/mL vs 0.09 ng/mL in survivors; P=0.004).
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