SUMMARY The inactivation of Semliki Forest virus by hydroxylamine was a first-order reaction. The ability of the partially inactivated virus to induce the production of infective virus, virus haemagglutinin, virus-induced RNA synthesis, virus-induced RNA polymerase and interferon were all inactivated with first-order kinetics. It is concluded that functional nucleic acid is essential for interferon production in this system.
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Skehel et al. (1968) studied this question.
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