Key result
Ventricular premature contractions >614 per 24 hours independently predicted cardiac death and ventricular tachycardia in patients with chronic Chagas' disease (HR 6.1; 95% CI 1.7-22.6; P=0.006).
Why the study?
What are the noninvasive prognostic markers for cardiac death and ventricular tachycardia in patients with chronic Chagas' disease?
Population
50 adult outpatients with chronic Chagas' disease, staged according to Los Andes class I, II or III…
Design
Cohort
Follow-up
84.2 ± 39.0 months
Authors
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High VPC burden may aid risk stratification in chronic Chagas disease; leaves open prospective validation and therapeutic impact.
Cohort (n=50)
What are the noninvasive prognostic markers for cardiac death and ventricular tachycardia in patients with chronic Chagas' disease?
Hazard Ratio: 6.1 (95% CI 1.7–22.6)
p-value: p=0.006
Apical aneurysms, reduced left ventricular function, and a high incidence of ventricular ectopic beats are strong independent predictors of cardiac death and ventricular tachycardia in chronic Chagas' disease.
Paulo Roberto Benchimol‐Barbosa (2007) conducted a cohort in chronic Chagas' disease (n=50). Ventricular premature contractions >614 per 24 h vs. ≤614 ventricular premature contractions per 24 h was evaluated on composite of cardiac death and ventricular tachycardia (HR 6.1, 95% CI 1.7-22.6, p=0.006). Ventricular premature contractions >614 per 24 hours independently predicted cardiac death and ventricular tachycardia in patients with chronic Chagas' disease (HR 6.1; 95% CI 1.7-22.6; P=0.006).
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