Why the study?
Is the number of heart neurons reduced in patients with dilated cardiomyopathy or Chagas's heart disease compared to normal subjects?
Population
15 hearts total: 7 from patients with dilated cardiomyopathy, 5 from normal subjects, and 3 from patients…
Design
Case-control
Authors
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May explain parasympathetic impairment in dilated cardiomyopathy; Level 4 case-control data leave open causality and clinical relevance.
Is the number of heart neurons reduced in patients with dilated cardiomyopathy or Chagas's heart disease compared to normal subjects?
Pathological examination reveals significant neuronal depopulation in the right atrium of patients with dilated cardiomyopathy and Chagas's disease, providing an anatomical basis for observed parasympathetic impairment.
Amorim et al. (1982) studied this question.
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