Population
Isolated guinea-pig taenia of the caecum
Comparison
X537A at varying concentrations (e.g., 10 M, 10 M) vs A23187, hypoxia, or untreated control
Design
Preclinical
Authors
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X537A's hypoxia-mimicking relaxation in guinea-pig muscle; leaves open ionophore relevance to mammalian cardiovascular energetics.
X537A induces relaxation in guinea-pig taenia smooth muscle likely through the inhibition of aerobic energy metabolism, contrasting with the contractile effects of A23187.
Ishida et al. (1982) studied this question.
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