Key result
Asymptomatic first-degree relatives of patients with premature coronary artery disease had a nearly two-fold higher odds of having abnormal coronary artery calcium scores compared to controls (OR 1.96).
Why the study?
Does a family history of premature coronary artery disease increase the frequency of abnormal coronary artery calcium scores in asymptomatic subjects?
Case-Control (n=673)
No
Does a family history of premature coronary artery disease increase the frequency of abnormal coronary artery calcium scores in asymptomatic subjects?
Odds Ratio: 1.96 (95% CI 1.04–3.67)
Absolute Event Rate: 26.3% vs 15.3%
p-value: p=<0.05
Asymptomatic first-degree relatives of patients with premature CAD have a two-fold higher odds of abnormal coronary artery calcium scores compared to controls, suggesting CAC scoring may improve risk assessment in this population.
May support CAC screening for risk stratification in relatives of premature CAD; hypothesis-generating and should not yet change practice.
BACKGROUND: To evaluate the frequency of positive coronary arteries calcium (CAC) scores in a unique population of asymptomatic first degree relatives (FDRs) of patients with angiographically confirmed early onset of coronary artery disease (CAD) and to assess their association with carotid ultrasound findings and other cardiovascular risk factors. METHOD AND RESULTS: We scanned, using 64-slice multi-detector computed tomography, 57 asymptomatic FDRs (47 ± 9 years old; 44% male, 56% female), out of the 111 FDRs previously phenotyped for cardiovascular (CV) risk factors. The controls were 616 individuals (57 ± 10 years old; 76% male, 24% female) with no family history of cardiovascular disease, chest pain or diabetes selected out of the 3500 subjects scanned between 2002 and 2007. FDRs had higher risk of abnormal CAC scores compared to controls; odds ratio (OR) for the 75th percentile was 1.96 (95% CI 1.04-3.67, p < 0.05). CONCLUSION: The frequency of abnormal CAC scores is two-fold higher in asymptomatic FDRs than in controls. CAC scan provides additional information on CV risk assessment in asymptomatic FDRs, particularly for those in the intermediate risk category. CLINICAL TRIAL REGISTRATION: NCT00387595.
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Taraboanta et al. (2012) conducted a case-control in Asymptomatic with family history of premature coronary artery disease (n=673). Family history of premature coronary artery disease vs. No family history of cardiovascular disease was evaluated on Abnormal coronary artery calcium (CAC) score (>75th percentile for age and gender) (OR 1.96, 95% CI 1.04-3.67, p=<0.05). Asymptomatic first-degree relatives of patients with premature coronary artery disease had a nearly two-fold higher odds of having abnormal coronary artery calcium scores compared to controls (OR 1.96).
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