What question did this study set out to answer?

To determine the maternal endocrine requirements and conceptus-derived factors necessary for luteal maintenance and the prevention of luteolysis during early ovine gestation.

April 5, 2019Bioscientifica ProceedingsOpen Access

Control of luteal function during early pregnancy in sheep

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Authors

JMJ. MartalDépartement Génétique Animale

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Implication

Laboratory study reveals hormonal regulation and embryonic trophoblastin secretion maintain luteal function in pregnant ewes, highlighting mechanisms that prevent pregnancy termination.

Key Points

To determine the maternal endocrine requirements and conceptus-derived factors necessary for luteal maintenance and the prevention of luteolysis during early ovine gestation.
Evaluated the roles of prolactin, luteinizing hormone, and conceptus presence in inhibiting prostaglandin F-2alpha-induced luteal regression in sheep.
Characterized the biochemical traits of trophoblastin isolated from the embryonic trophoblast, assessing thermolability, pronase sensitivity, pH 9.6 solubility, and chromatographic migration on Ultrogel.
Prolactin and luteinizing hormone are required to maintain normal luteal morphology, while the presence of the conceptus effectively inhibits prostaglandin F-2alpha-induced luteolysis.
The trophoblast secretes trophoblastin, a heat-labile and pronase-inactivated protein soluble at pH 9.6 that is active between gestation days 12 and 22, exerting anti-luteolytic effects that persist for several months.

Cite This Study

J. Martal (2019) studied this question.

synapsesocial.com/papers/6a883bd9aaaef52b1e4df76b https://doi.org/10.1530/biosciprocs.1.019

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Implication

Laboratory study reveals hormonal regulation and embryonic trophoblastin secretion maintain luteal function in pregnant ewes, highlighting mechanisms that prevent pregnancy termination.

Control of luteal function during early pregnancy in sheep

Discussion

Member takes

Implication

Key Points

Cite This Study

Control of luteal function during early pregnancy in sheep

Discussion

Member takes

Implication

Key Points

Cite This Study

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