A novel and simple approach to prepare monodispersed chitosan microspheres with relative small size and controlled structures was developed by combining the solidification methods of solvent extraction and chemical crosslinking in a capillary-embedded microfluidic decive. The microspheres with different structures are used in the field of protein drug controlled release and immobilization lipases and they show different release profiles and good stability, respectively.
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Xu et al. (2011) studied this question.
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