Key result
Advancing stages of chronic kidney disease in diabetic patients were associated with a significant stepwise increase in left ventricular mass index (P<0.001) and decrease in ejection fraction (P=0.038).
Cross-Sectional (n=285)
No
p-value: p=<0.001
Advancing stages of chronic kidney disease in diabetic patients are associated with progressive worsening of left ventricular mass index and ejection fraction.
Supports closer cardiac surveillance in diabetic CKD progression; hypothesis-generating and requires prospective studies before practice implications.
AIMS: Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD). METHODS: This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 from our outpatient department of internal medicine. Clinical and echocardiographic parameters were compared and analyzed. RESULTS: We found a significant stepwise increase in LVMI (P < 0.001), LVH (P < 0.001), and LVEF <55% (P = 0.013) and a stepwise decrease in LVEF (P = 0.038) corresponding to advance in CKD stages. CONCLUSIONS: Our findings suggest that increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes.
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Chen et al. (2011) conducted a cross-sectional in Diabetic patients with chronic kidney disease (n=285). Advance in CKD stages was evaluated on Left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) (p=<0.001). Advancing stages of chronic kidney disease in diabetic patients were associated with a significant stepwise increase in left ventricular mass index (P<0.001) and decrease in ejection fraction (P=0.038).
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