Why the study?
Does the presence of titin antibodies correlate with disease severity in late-onset non-thymoma MG patients?
Population
21 thymectomized patients with onset of Myasthenia Gravis (MG) after 40 years of age and without thymoma
Comparison
Presence of titin antibodies vs Absence of titin antibodies
Design
Cohort
Authors
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Titin antibodies may flag higher-risk late-onset MG for closer monitoring; leaves open whether they should guide therapy.
Does the presence of titin antibodies correlate with disease severity in late-onset non-thymoma MG patients?
The presence of circulating titin antibodies in late-onset non-thymoma MG patients is associated with more severe disease and higher use of immunosuppressive drugs.
Skeie et al. (1995) studied this question.
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