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April 3, 2012Current Opinion in Anaesthesiology

Caesarean delivery vasopressor management

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Key result

Phenylephrine is the current vasopressor of choice for preventing maternal hypotension and nausea during spinal anaesthesia for caesarean delivery.

Why the study?

Does phenylephrine prevent maternal hypotension and nausea during spinal anaesthesia for caesarean delivery?

Population

Pregnant women undergoing caesarean delivery under spinal anaesthesia

Design

Review

Authors

DCDavid W. CooperIndiana Hand to Shoulder Center

Discussion

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Implication

Requires titration to avoid hypertension in caesarean spinal anaesthesia; leaves open comparative trials with alternatives.

Structured PICO

Does phenylephrine prevent maternal hypotension and nausea during spinal anaesthesia for caesarean delivery?

P
Population
Pregnant women undergoing caesarean delivery under spinal anaesthesia
I
Intervention
Vasopressor administration (specifically phenylephrine)
O
Outcome
Maternal and fetal effects (maternal hypotension, nausea, cardiac output, fetal acidosis)safety

Phenylephrine is the preferred vasopressor for preventing maternal hypotension during spinal anaesthesia for caesarean delivery, but requires careful titration to avoid hypertension.

Cite This Study

David W. Cooper (2012) conducted a review in Spinal anaesthesia for caesarean delivery. Vasopressor administration (phenylephrine) was evaluated. Phenylephrine is the current vasopressor of choice for preventing maternal hypotension and nausea during spinal anaesthesia for caesarean delivery.

synapsesocial.com/papers/6a88435d8dfe8b7ec5a54066https://doi.org/10.1097/aco.0b013e3283530d62
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining intra‐operative hypotension – a pilot comparison of blood pressure during sleep and general anaesthesia*2011 · 26 citations
  2. 2The Effect of Maternal and Fetal β2-Adrenoceptor and Nitric Oxide Synthase Genotype on Vasopressor Requirement and Fetal Acid-Base Status During Spinal Anesthesia for Cesarean Delivery2011 · 35 citations
  3. 3The Clinical Implications of Isolated Alpha1 Adrenergic Stimulation2011 · 124 citations
  4. 4The Physiologic Implications of Isolated Alpha1 Adrenergic Stimulation2011 · 112 citations
  5. 5Evaluation of the Influence of the Codon 16 Polymorphism of the Beta-2 Adrenergic Receptor Gene on the Incidence of Arterial Hypotension and Ephedrine Use in Pregnant Patients Submitted to Subarachnoid Anesthesia2010 · 10 citations