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May 1, 1982Molecular and Cellular Biology

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

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Authors

JMJeffrey N. MastersCalifornia Institute of TechnologyBKBenneta KeeleyCalifornia Institute of TechnologyHGH Gay

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Masters et al. (1982) studied this question.

synapsesocial.com/papers/6a8845e12c11edba2ecf1ca7https://doi.org/10.1128/mcb.2.5.498
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and characterization of dihydrofolic acid reductase from methotrexate-sensitive and -resistant human cell lines.1981 · 28 citations
  2. 2Relation of Folic Acid Reductase to Amethopterin Resistance in Cultured Mammalian Cells1961 · 207 citations
  3. 3HeLa cells resistant to bromodeoxyuridine and deficient in thymidine kinase activity1966 · 88 citations
  4. 4Double Minutes in Human Carcinoma Cell Lines, With Special Reference to Breast Tumors 21979 · 76 citations