Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block
Key result
In myocytes from dogs with chronic atrioventricular block, the dynamic modulation of L-type Ca2+ current by SR Ca2+ release was significantly larger than in control (23% vs 13%; P<0.05).
Population
Hypertrophied cardiac myocytes from dogs with chronic atrioventricular block (cAVB)
Comparison
Beta-adrenergic stimulation and manipulation of… vs Cardiac myocytes from control dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May increase EAD susceptibility under beta-stimulation in chronic AV block; leaves open translation to human arrhythmia mechanisms.
Structured PICO
P
Population
Hypertrophied cardiac myocytes from dogs with chronic atrioventricular block (cAVB)
E
Exposure
Beta-adrenergic stimulation and manipulation of sarcoplasmic reticulum (SR) Ca2+ release
C
Comparator
Cardiac myocytes from control dogs
O
Outcome
Properties of window L-type Ca2+ current (ICaL) and its dynamic modulation by SR Ca2+ releasesurrogate
Main Result
Absolute Event Rate: 23% vs 13%
p-value: p=<0.05
In a canine model of chronic AV block, enhanced dynamic modulation of a larger, rightward-shifted window L-type Ca2+ current by SR Ca2+ release contributes to increased susceptibility to early afterdepolarizations under beta-adrenergic stimulation.
Cite This Study
Antoons et al. (2006) studied Chronic atrioventricular block with cardiac hypertrophy. Chronic atrioventricular block (cAVB) vs. Control was evaluated on Extent of dynamic modulation of ICaL by SR Ca2+ release (p=<0.05). In myocytes from dogs with chronic atrioventricular block, the dynamic modulation of L-type Ca2+ current by SR Ca2+ release was significantly larger than in control (23% vs 13%; P<0.05).