Key result
Venous occlusion plethysmography is a non-invasive technique used to quantify limb blood flow in peripheral artery disease, though literature suggests wide methodological variability in its measurement.
This review highlights the methodological variability in using venous occlusion plethysmography to measure limb blood flow in PAD patients, emphasizing the need for standardized approaches.
Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. exercise training, revascularization, and pharmacological agents). Venous occlusion plethysmography (VOP) is a century-old, non-invasive technique used to quantify limb blood flow and has been used to evaluate hemodynamic compromise in patients with PAD. However, the literature suggests a wide array of methodological variability in the measurement and analysis of limb blood flow using VOP. In this manuscript, we overview the clinical application of VOP measurement, and secondly we review the methodological variation that occurs during the measurement and analysis of VOP in healthy individuals and in patients with claudication.
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Salisbury et al. (2018) conducted a review in Peripheral artery disease. Venous occlusion plethysmography (VOP) was evaluated. Venous occlusion plethysmography is a non-invasive technique used to quantify limb blood flow in peripheral artery disease, though literature suggests wide methodological variability in its measurement.
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