Key result
Ropivacaine resulted in shorter corrected QT, dispersion of QT, and corrected dispersion of QT intervals compared with bupivacaine during thoracic epidural combined with general anaesthesia (p<0.05).
Why the study?
Does ropivacaine compared to bupivacaine reduce QT interval prolongation in patients undergoing thoracic surgery under combined epidural and general anaesthesia?
Population
30 ASA physical status 1-3 patients requiring thoracic epidural anaesthesia combined with general…
Comparison
Ropivacaine at an average dose of 1.5 mL/segment… vs Bupivacaine at an average dose of 1.5 mL/segment…
Design
RCT, randomly assigned
Follow-up
up to the 5th min of endobronchial intubation
Authors
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Ropivacaine may be preferred over bupivacaine in thoracic epidural anesthesia to limit QT prolongation risk; extends comparative cardiac safety data for local anesthetics.
RCT (n=30)
randomly assigned
Does ropivacaine compared to bupivacaine reduce QT interval prolongation in patients undergoing thoracic surgery under combined epidural and general anaesthesia?
p-value: p=<0.05
Ropivacaine may be associated with less prolongation of corrected QT and QT dispersion compared to bupivacaine during thoracic epidural anaesthesia.
Sazak et al. (2013) conducted an RCT in Thoracic surgery requiring thoracic epidural anaesthesia combined with general anaesthesia (n=30). Ropivacaine vs. Bupivacaine was evaluated on QT interval, corrected QT, dispersion of QT, and corrected dispersion of QT (p=<0.05). Ropivacaine resulted in shorter corrected QT, dispersion of QT, and corrected dispersion of QT intervals compared with bupivacaine during thoracic epidural combined with general anaesthesia (p<0.05).
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