Key result
In a pediatric cohort with long QT syndrome, females exhibited significantly longer QTc intervals (564.57 ms vs 502.25 ms) and a later age of onset compared to males.
Why the study?
The study was conducted to elucidate the genetic and clinical characteristics of children diagnosed with long QT syndrome at a single institution.
Population
15 children diagnosed with congenital LQTS
Design
Single-center retrospective study
Authors
Loading...
Sex differences may inform monitoring in pediatric LQTS; leaves open confirmation of mutation patterns in larger prospective cohorts.
Observational (n=15)
No
Absolute Event Rate: 564.57% vs 502.25%
p-value: p=0.008
In pediatric LQTS, females present later and with longer QTc intervals than males, and the majority of cases are driven by inherited KCNQ1 missense mutations.
Li et al. (2025) conducted an observational in Long QT syndrome (n=15). Female sex vs. Male sex was evaluated on QTc interval (ms) (p=0.008). In a pediatric cohort with long QT syndrome, females exhibited significantly longer QTc intervals (564.57 ms vs 502.25 ms) and a later age of onset compared to males.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: