Population
Xenopus laevis oocytes expressing wild-type and 48 cysteine-substituted mutant HERG channels
Comparison
Cysteine-scanning mutagenesis and application of… vs Wild-type (WT) HERG channels
Design
Preclinical
Authors
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HERG S5-P linker alpha-helix links inactivation to voltage sensing; leaves open translation to human channelopathies or antiarrhythmic targets.
The 583-597 segment in the S5-P linker of the HERG channel forms an alpha-helix that serves as a communication bridge between the outer mouth and voltage sensor, critical for its unique C-type inactivation.
Liu et al. (2002) studied this question.
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