Population
Synthetic 42-residue peptide corresponding to the S5P extracellular linker region of the HERG K+ channel
Comparison
Structural analysis in SDS micelles and… vs Aqueous solution (for structural analysis)
Design
Preclinical
Authors
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Does not change arrhythmia management; extends structural models of HERG inactivation for future research.
The study elucidates the structure of the HERG K+ channel S5P linker, revealing two helical regions that interact with the pore to facilitate rapid inactivation.
Torres et al. (2003) studied this question.
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