May 1, 2002Journal of Biological ChemistryOpen Access

Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels

View Full Paper

Ask AI

Bookmark

Structured PICO

Population

HERG (human ether-a-go-go-related gene) K(+) channels (D540K mutant models)

Intervention

Site-directed mutagenesis of S6 domain residues (Ile(662)-Tyr(667) to Ala, Arg(665) to Gln or Asp) and S4-S5 linker (D540R, D540K/R665K)

Outcome

Hyperpolarization-dependent reopening of HERG channelssurrogate

The C-terminal ends of S4 and S6 in HERG K+ channels are in close proximity at hyperpolarized potentials, with Arg(665) interacting with Lys(540) via electrostatic repulsion to modulate gating.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Clarifies S4-S6 electrostatic gating in HERG; leaves open relevance to human channelopathies or drug effects.

Cite This Study

Tristani‐Firouzi et al. (2002) studied this question.

synapsesocial.com/papers/6a7b9fd5b6db831c5f75d2a4 https://doi.org/10.1074/jbc.m200410200

View Full Paper

Ask AI

Bookmark

Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels

Structured PICO

Discussion

Implication

Cite This Study

Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider