March 9, 2006Journal of Biological ChemistryOpen Access

The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-á-go-go-related Gene (hERG) K+ Channel

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Population

hERG and ether-a'-go-go (EAG) K+ channels (chimeras and cysteine mutants including D540C-L666C)

Design

Preclinical

Authors

TFTania FerrerUniversidad de Colima JRJason RuppUniversity of Washington DPDavid R. PiperThermo Fisher Scientific (United States)

Discussion

Member takes

Implication

Does not inform clinical arrhythmia management; extends mechanistic models of hERG voltage-sensor coupling for targeted studies.

Structured PICO

Population

hERG and ether-a'-go-go (EAG) K+ channels (chimeras and cysteine mutants including D540C-L666C)

Intervention

Introduction of cysteines in the S4-S5 linker and at the C-terminal end of the S6 domain, followed by exposure to an oxidizing environment

Outcome

Channel current and gating currents to assess voltage sensor movement and channel statesurrogate

Specific interactions between the S4-S5 linker and the activation gate directly couple voltage sensor movement to channel opening and stabilize the closed conformation of the hERG K+ channel.

Cite This Study

Ferrer et al. (2006) studied this question.

synapsesocial.com/papers/6a7e07c1968fa26fcacb570e https://doi.org/10.1074/jbc.m513518200

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The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-á-go-go-related Gene (hERG) K+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The S4-S5 Linker Directly Couples Voltage Sensor Movement to the Activation Gate in the Human Ether-á-go-go-related Gene (hERG) K+ Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider