Population
Engineered human ether-à-go-go-related gene (hERG) potassium channels
Comparison
Introduction of cysteine pairs and exposure to… vs Single-cysteine mutants and exposure to reducing…
Design
Preclinical
Authors
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Hypothesis-generating for hERG-related repolarization disorders; leaves open whether N-terminus–S4-S5 interactions are viable therapeutic targets.
This study provides direct molecular evidence that physical interactions between the N-terminus and the S4-S5 linker are essential for hERG channel gating, which is critical for cardiac repolarization.
Peña et al. (2011) studied this question.
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