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January 1, 2004Sunhwan'giOpen Access

Moleculogenetic Characteristics of the Patient with Long QT Syndrome in Korean

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Population

10 patients diagnosed with congenital long QT syndrome (LQTS) in Korea, 90% female.

Design

Case_series

Authors

DHDae Woo HyunYKYoon Nyun KimSHSeong Wook Han

Discussion

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Overview

Supports HERG/KvLQT1 predominance for Korean LQTS screening; leaves open generalizability from this small case series.

Structured PICO

P
Population
10 patients diagnosed with congenital long QT syndrome (LQTS) in Korea, 90% female.
I
Intervention
Genetic mutation analysis (KvLQT1, HERG, KCNE1) from blood DNA.
O
Outcome
Presence of genetic mutations in KvLQT1, HERG, and KCNE1.surrogate

In a small Korean cohort of congenital LQTS patients, genetic mutations were predominantly found in the HERG and KvLQT1 genes.

Limitations

  • Small sample size requiring further organized study in more individuals

Cite This Study

Hyun et al. (2004) studied this question.

synapsesocial.com/papers/6a88480fa082a64c2914c4ddhttps://doi.org/10.4070/kcj.2004.34.8.813
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long QT Syndrome: a Korean Single Center Study2013 · 15 citations
  2. 2Gene Sequencing in Neonates and Infants with the Long QT Syndrome2005 · 26 citations
  3. 3Genotype and clinical characteristics of congenital long QT syndrome in Thailand2018 · 9 citations
  4. 4Clinical and Electrocardiographic Features of Patients with Congenital Long QT Syndrome2002 · 3 citations
  5. 5Clinical characteristics of patients with various genetic types of long QT syndrome2022 · 2 citations