Key result
Mental stress testing identified concealed LQTS with 97% sensitivity and 97% specificity using a QT variation cut-off > -11 ms, revealing a paradoxical QT response in mutation carriers.
Why the study?
Does the mental stress test accurately diagnose concealed long QT syndrome in mutation carriers without baseline QT prolongation?
Population
70 patients, including 36 carriers of KCNQ1 or KCNH2 mutations without baseline QT prolongation, and 34…
Comparison
Mental stress test with electrocardiogram… vs Control group of patients with negative exercise…
Design
Case-control
Authors
Loading...
Supports diagnostic utility of mental stress testing in concealed LQTS; leaves open prospective validation before clinical adoption.
Case-Control (n=70)
Does the mental stress test accurately diagnose concealed long QT syndrome in mutation carriers without baseline QT prolongation?
p-value: p=< 0.0001
The mental stress test is a highly sensitive and specific method to unmask concealed long QT syndrome in mutation carriers with normal baseline QT intervals.
Etienne et al. (2018) conducted a case-control in Concealed long QT syndrome (n=70). Mental stress test vs. Controls with negative exercise and epinephrine tests was evaluated on QT duration variation during mental stress test (p=< 0.0001). Mental stress testing identified concealed LQTS with 97% sensitivity and 97% specificity using a QT variation cut-off > -11 ms, revealing a paradoxical QT response in mutation carriers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: