January 1, 2001Annals of Noninvasive ElectrocardiologyOpen Access

QTc was as variable in carriers of the same mutation as it was among carriers with different HERG mutations (P = 0.19), and a strong association was found between QTc and the occurrence of cardiac events.

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Population

469 individuals from 5 large LQTS families, each family with a different mutation of the HERG gene.

Design

Cohort

Follow-up

2 to 7 years

Authors

JBJesaia Benhorin AMArthur J. Moss WZWojciech Zaręba

Discussion

Member takes

Overview

QTc variability within identical HERG mutations was associated with events; supports modifier gene effects but leaves risk stratification open.

Structured PICO

Population

469 individuals from 5 large LQTS families (69% genotyped, 102 carriers), each family with a different mutation of the HERG gene (LQT2).

Outcome

QTc duration, frequency of cardiac events (syncope and LQTS-related cardiac arrest/death), and T-wave morphologysurrogate

The clinical expression of LQT2 is highly variable even among carriers of the same HERG mutation, suggesting that modifier genes significantly influence the phenotype.

Cite This Study

Benhorin et al. (2001) studied this question.

synapsesocial.com/papers/6a8848f4fc0635f4eccf0e28 https://doi.org/10.1111/j.1542-474x.2001.tb00137.x

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January 1, 2001Annals of Noninvasive ElectrocardiologyOpen Access

QTc was as variable in carriers of the same mutation as it was among carriers with different HERG mutations (P = 0.19), and a strong association was found between QTc and the occurrence of cardiac events.

View Full Paper

Ask AI

Bookmark

Population

469 individuals from 5 large LQTS families, each family with a different mutation of the HERG gene.

Design

Cohort

Follow-up

2 to 7 years

Authors

JBJesaia Benhorin AMArthur J. Moss WZWojciech Zaręba

Discussion

Member takes

Overview

QTc variability within identical HERG mutations was associated with events; supports modifier gene effects but leaves risk stratification open.

Structured PICO

Population

469 individuals from 5 large LQTS families (69% genotyped, 102 carriers), each family with a different mutation of the HERG gene (LQT2).

Outcome

QTc duration, frequency of cardiac events (syncope and LQTS-related cardiac arrest/death), and T-wave morphologysurrogate

The clinical expression of LQT2 is highly variable even among carriers of the same HERG mutation, suggesting that modifier genes significantly influence the phenotype.

Cite This Study

Benhorin et al. (2001) studied this question.

synapsesocial.com/papers/6a8848f4fc0635f4eccf0e28 https://doi.org/10.1111/j.1542-474x.2001.tb00137.x

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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