What question did this study set out to answer?

Assess how pharmacological manipulation of GABAA and NMDA receptors alters regional dopamine D2/3 receptor binding across nigrostriatal and mesolimbic circuits in rats.

July 3, 2020Reviews in the Neurosciences

GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat

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Authors

SNSusanne NikolausKlinik und Poliklinik für Nuklearmedizin MBMarkus BeuKlinik und Poliklinik für Nuklearmedizin HWHans‐Jörg WittsackDüsseldorf University Hospital

Discussion

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Implication

Preclinical imaging study reveals distinct GABAergic and glutamatergic modulation of dopamine release across rat brain networks, highlighting divergent roles of GABAA and NMDA receptors.

Key Points

Assess how pharmacological manipulation of GABAA and NMDA receptors alters regional dopamine D2/3 receptor binding across nigrostriatal and mesolimbic circuits in rats.
Measured baseline and post-injection [123I]iodobenzamide binding to dopamine D2/3 receptors across subcortical, cortical, and hippocampal regions using small-animal SPECT.
Administered systemic challenges with the GABAA agonist muscimol (1 mg/kg), GABAA antagonist bicuculline (1 mg/kg), NMDA agonist d-cycloserine (20 mg/kg), or NMDA antagonist amantadine (40 mg/kg).
Muscimol significantly reduced D2/3 receptor binding across five regions (nucleus accumbens, caudateputamen, substantia nigra/ventral tegmental area, thalamus, and posterior hippocampus), whereas amantadine-induced reductions were confined to the nucleus accumbens, caudateputamen, and thalamus.
D-cycloserine elevated D2/3 receptor binding broadly across eight subcortical and cortical regions, while bicuculline-induced increases were restricted to the caudateputamen and thalamus.
GABAA agonists shared functional profiles with NMDA antagonists, whereas GABAA antagonists mirrored NMDA agonists, with receptor agonism consistently influencing a broader distribution of brain areas.

Cite This Study

Nikolaus et al. (2020) studied this question.

synapsesocial.com/papers/6a8849486304c7fd8e4dfcca https://doi.org/10.1515/revneuro-2019-0112

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Implication

Preclinical imaging study reveals distinct GABAergic and glutamatergic modulation of dopamine release across rat brain networks, highlighting divergent roles of GABAA and NMDA receptors.

GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat

Discussion

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Implication

Key Points

Cite This Study

GABAergic and glutamatergic effects on nigrostriatal and mesolimbic dopamine release in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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