Key result
Among patients with amaurosis fugax, carotid artery stenosis was present in 35.3% and was significantly associated with subsequent stroke (18.0% vs 4.5%; P=0.003).
Why the study?
The study was conducted to determine the associations among carotid stenosis, stroke, and myocardial infarction in patients with amaurosis fugax.
What is the association between carotid stenosis and subsequent stroke or myocardial infarction in patients with amaurosis fugax?
Observational (n=173)
No
What is the association between carotid stenosis and subsequent stroke or myocardial infarction in patients with amaurosis fugax?
Absolute Event Rate: 18% vs 4.5%
p-value: p=0.003
In patients with amaurosis fugax, underlying carotid artery stenosis is common and significantly associated with subsequent stroke and central retinal artery occlusion, but not myocardial infarction.
May aid stroke risk stratification in amaurosis fugax; observational data leave open screening and intervention trials.
Background: To determine the associations among carotid stenosis, stroke, and myocardial infarction (MI) in patients with amaurosis fugax (AF). Methods: We retrospectively reviewed the records of patients diagnosed as having AF between January 2000 and December 2019. Among 14,857 patients with AF initially reviewed in the database, only 173 were ultimately enrolled, after excluding patients with wrong diagnosis, insufficient medical records, or loss of follow-up. Results: Of the 173 patients with AF, 61 (35.3%) had carotid stenosis, and among them, 18 (10.4%) had severe stenosis. In multivariate regression analysis, carotid stenosis was significantly associated with age (p = 0.009), male sex (p = 0.006), and ischemic heart disease (p = 0.039). Sixteen (9.2%) patients experienced a stroke after AF diagnosis (mean time to stroke: 23.1 ± 31.1 months, range: 1 day~85 month), 11 (68.8%) of whom had carotid artery stenosis (p = 0.003). Three (1.7%) patients had MI after AF (mean time to MI: 24.8 ± 35.9 months, range: 12 days~66 months), none of whom had carotid artery stenosis (p = 0.553). Four (2.3%) patients had central retinal artery occlusion (CRAO) after AF, all of whom had carotid artery stenosis (p = 0.034). Conclusions: A high incidence of internal carotid artery stenosis was observed after AF attack and was significantly associated with stroke. The incidence of MI and CRAO after AF was low. Among them, only CRAO was associated with carotid artery stenosis.
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Sun et al. (2022) conducted an observational in Amaurosis fugax (n=173). Carotid stenosis vs. No carotid stenosis was evaluated on Stroke after amaurosis fugax diagnosis (p=0.003). Among patients with amaurosis fugax, carotid artery stenosis was present in 35.3% and was significantly associated with subsequent stroke (18.0% vs 4.5%; P=0.003).
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