What question did this study set out to answer?

To identify specific autoantibodies associated with sensory neuropathy and sensory neuronopathy in patients presenting with autoimmune or idiopathic etiologies.

January 27, 2015Journal of Neurology Neurosurgery & Psychiatry

Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy

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Authors

JAJ.‐C. AntoineCentre Hospitalier Universitaire de Saint-Étienne NBNadia BoutaharCentre Hospitalier Universitaire de Saint-Étienne FLFrançois LassablièreUniversité Jean Monnet

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Implication

Case-control study reveals anti-FGFR3 antibodies in sensory neuropathy patients, highlighting a targeted autoimmune mechanism in sensory neurons.

Key Points

To identify specific autoantibodies associated with sensory neuropathy and sensory neuronopathy in patients presenting with autoimmune or idiopathic etiologies.
Screened serum samples using an 8,000 human protein array to identify autoantibody targets in 16 sensory neuronopathy cases and 30 controls.
Tested candidate antibodies via ELISA and cell-based assays in a cohort of 106 sensory neuropathy patients (including 72 with sensory neuronopathy) and 211 controls (including sensorimotor neuropathy, other neurological diseases, systemic autoimmune diseases, and healthy donors).
Anti-FGFR3 antibodies against the intracellular domain were detected in 16/106 sensory neuropathy patients and 1/211 controls (p < 0.001), conferring 19% sensitivity, 99.6% specificity, 94.1% positive predictive value, and 77.3% negative predictive value.
Among sensory neuropathy cases, anti-FGFR3 antibodies occurred in 11/38 patients with an autoimmune context and 5/46 with idiopathic neuropathy, but in 0/22 with neuropathies of other etiologies (p = 0.006).
Seropositive patients predominantly displayed non-length dependent neuropathy (87%), met criteria for probable sensory neuronopathy (82%), and frequently exhibited pain and trigeminal nerve involvement.

Cite This Study

Antoine et al. (2015) studied this question.

synapsesocial.com/papers/6a884d7e6304c7fd8e4dfdc6 https://doi.org/10.1136/jnnp-2014-309730

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Implication

Case-control study reveals anti-FGFR3 antibodies in sensory neuropathy patients, highlighting a targeted autoimmune mechanism in sensory neurons.

Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Antifibroblast growth factor receptor 3 antibodies identify a subgroup of patients with sensory neuropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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