Despite the known physiological roles of K(2P) channels, few phenotypic traits in knockout mice are directly linked to their pH sensitivity.
Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K(2P) channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K(2P) channels.
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Lesage et al. (2011) conducted a review in pH-Sensitive Background K2P Channels. Gene inactivation of K(2P) channels was evaluated.
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