Key result
Regulation of the inflammatory reflex via vagal modulation appears to be a useful potential interventional strategy for the treatment of severe sepsis and septic shock.
Why the study?
Does vagal modulation of the immune system improve outcomes in severe sepsis and septic shock?
Population
Patients or experimental models with severe sepsis and septic shock
Design
Review
Authors
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Vagal modulation remains investigational in sepsis; leaves open need for RCTs before any practice change.
Does vagal modulation of the immune system improve outcomes in severe sepsis and septic shock?
This review highlights the potential of targeting the vagus nerve-mediated inflammatory reflex as a therapeutic strategy for severe sepsis and septic shock.
Wang et al. (2016) conducted a review in Sepsis. Vagal modulation of the immune system was evaluated. Regulation of the inflammatory reflex via vagal modulation appears to be a useful potential interventional strategy for the treatment of severe sepsis and septic shock.
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