Key result
Palmitoleic acid treatment attenuated body weight gain, prevented epididymal adipocyte hypertrophy, and decreased pro-inflammatory cytokine expression in vascular stromal cells of obese mice.
Why the study?
Molecules that induce the emergence of new and functional adipocytes in adipose tissue may alleviate or prevent inflammatory and metabolic disorders, prompting investigation into palmitoleic acid.
Population
C57BL/6j mice fed control or HFD, 3T3-L1 cells, and primary pre-adipocytes
Comparison
Palmitoleic acid treatment vs control or HFD
Design
Preclinical animal and cell-culture study
Follow-up
4 weeks
Authors
Loading...
Hypothesis-generating for palmitoleic acid in obesity; human studies required before any clinical consideration.
Palmitoleic acid prevents adipocyte hypertrophy and reduces pro-inflammatory cytokine expression in a mouse model of diet-induced obesity.
Simão et al. (2022) studied Obesity. Palmitoleic acid (n7) vs. High-fat diet without n7 was evaluated on Body weight, epididymal fat mass, adipocyte size, and inflammatory markers. Palmitoleic acid treatment attenuated body weight gain, prevented epididymal adipocyte hypertrophy, and decreased pro-inflammatory cytokine expression in vascular stromal cells of obese mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: