Key result
Isoflurane-based anesthesia resulted in a 38.4% incidence of postoperative cognitive dysfunction compared to 48.8% with propofol-based anesthesia, with no significant difference (P=0.097).
Why the study?
Postoperative cognitive dysfunction is a frequent complication following cardiac surgery, but the role of the anesthetic agent remains uncertain.
Does isoflurane-based anesthesia compared to propofol-based anesthesia reduce postoperative cognitive dysfunction in patients undergoing elective open heart surgery?
RCT (n=260)
Does isoflurane-based anesthesia compared to propofol-based anesthesia reduce postoperative cognitive dysfunction in patients undergoing elective open heart surgery?
Absolute Event Rate: 38.4% vs 48.8%
p-value: p=0.097
There appears to be no significant difference in the incidence of early postoperative cognitive dysfunction between isoflurane-based and propofol-based anesthesia for open heart surgery.
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Kamel et al. (2019) conducted an RCT in Elective open heart surgery (n=260). Isoflurane-based anesthesia vs. Propofol-based anesthesia was evaluated on Postoperative cognitive dysfunction (POCD) (p=0.097). Isoflurane-based anesthesia resulted in a 38.4% incidence of postoperative cognitive dysfunction compared to 48.8% with propofol-based anesthesia, with no significant difference (P=0.097).
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