Key result
Repeated platelet aggregation testing in healthy controls showed responses were within the acceptable range only 67% of the time over a 5-year period.
Why the study?
Do platelet aggregation responses vary over time in healthy controls?
Observational (n=7)
No
Do platelet aggregation responses vary over time in healthy controls?
Platelet aggregation responses can vary significantly over time even in healthy individuals, suggesting that a repeat study is prudent before diagnosing a platelet abnormality.
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Variability in healthy controls cautions against single-test platelet diagnoses; leaves open need for standardized protocols and prospective validation.
Refaai et al. (2010) conducted an observational in Healthy controls (n=7). Repeated platelet aggregation testing was evaluated on Platelet aggregations within the acceptable range. Repeated platelet aggregation testing in healthy controls showed responses were within the acceptable range only 67% of the time over a 5-year period.
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